What is a GIP-GLP-1?

GIP-GLP-1

●GIP-GLP-1s are once-weekly injectable dual glucagon-like peptide 1 (GLP-1) receptor and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. It works by increasing insulin production and lowers glucagon secretion as well as targets areas in the brain that regulate appetite and food intake. A small change in the molecule allows the drug to last weeks in our bodies rather than the natural version our bodies make, which lasts minutes.

How Do GIP-GLP-1s Work?

● Delays how quickly our stomachs digest food leading to a feeling of fullness and satisfaction with smaller meal sizes.

● Slows intestinal motility so you will feel fuller longer after meals.

● Dual action receptor allows for lower blood sugars, in part by reducing the production of sugar in the liver.

● Stimulates insulin secretion by the pancreas.

● GIP increases energy expenditure, resulting in weight loss reductions.

Benefits of GIP-GLP-1

● Decreased appetite and cravings

● Weight loss

● A1C reduction

● Improved cardiometabolic measures

Side Effects/Contraindications

●The most common side effects include nausea and constipation. Patients also report acid reflux, stomach pain, vomiting, and diarrhea. Serious side effects include pancreatitis, gallbladder issues, kidney failure, and changes in vision. The risk of serious side effects increases in patients with hypoglycemia, kidney problems, and risk of allergic reactions. This medication is not insulin and should not be used if you have type 1 diabetes or if you develop diabetic ketoacidosis. GIP-GLP-1 should not be used with any other GLP-1 medications.

RISK OF THYROID C−CELL TUMORS. If you or any family members have been diagnosed with Multiple Endocrine Neoplasia Syndrome Type 2 or Medullary thyroid cancer you should not take GIP-GLP-1. If you have ever had pancreatitis consult with your medical provider as using GIP-GLP-1 can increase the risk of developing pancreatitis.